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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Ilexgenin A, Sorafenib
Phytochemical Name Ilexgenin A (PubChem CID: 21672638 )
Anticancer drug Name Sorafenib (PubChem CID: 216239 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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The theory of cold and heat
Drug Name Sorafenib
Adverse Reactions Facial red macules, dry skin, acne, alveolitis. This was inferred hot nature anticancer drug.
Recommendations Cold: Ilex hainanensis; Mangifera indica; Camellia sinensis; Sophora flavescens; Eriobotrya japonica; Citrus aurantium;
Reference Malignant tumors in the era of immunotherapy based on traditional Chinese medicine's "cold and hot theory" Construction of integrated traditional Chinese and Western medicine treatment paradigm[J]. Modern Journal of Integrated Traditional Chinese and Western Medicine,2023,32(12):1712-1716. DOI:10.3969/j.issn.1008-8849.2023.12.022.　　ref_link
Combination Pair ID: 261
Ref_1
Pair Name Ilexgenin A, Sorafenib
Disease Info [ICD-11: 2C12] Hepatocellular carcinoma Investigative
Biological Phenomena Inhibition-->Angiogenesis
Gene Regulation Up-regulation Expression CASP3 hsa836
Up-regulation Expression CASP7 hsa840
Down-regulation Expression IL6 hsa3569
Down-regulation Expression MVD hsa4597
Down-regulation Expression PIK3CA hsa5290
Down-regulation Expression STAT3 hsa6774
Down-regulation Expression TNF hsa7124
Down-regulation Expression VEGFA hsa7422
In Vitro Model Hep-G2 Hepatoblastoma Homo sapiens (Human) CVCL_0027
Result The results described in the present study identifies Ilexgenin A as a promising therapeutic candidate that modulates inflammation, angiogenesis, and HCC growth.
03. Reference
No. Title Href
1 Ilexgenin A exerts anti-inflammation and anti-angiogenesis effects through inhibition of STAT3 and PI3K pathways and exhibits synergistic effects with Sorafenib on hepatoma growth. Toxicol Appl Pharmacol. 2017 Jan 15;315:90-101. doi: 10.1016/j.taap.2016.12.008. Click
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